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Cannabis extract relieved muscle stiffness in patients with MS

John P. Zajicek, PhD, Professor of Clinical Neuroscience at the Neurology Research and Clinical Trials Unit of the Peninsula Medical School at the University of Plymouth, et al., wrote the following in a Nov. 2012 study titled "Multiple Sclerosis and Extract of Cannabis: Results of the MUSEC Trial," published in the Journal of Neurology, Neurosurgery & Psychiatry:

Quote:"OBJECTIVE: Multiple sclerosis (MS) is associated with chronic symptoms, including muscle stiffness, spasms, pain and insomnia. Here we report the results of the Multiple Sclerosis and Extract of Cannabis (MUSEC) study that aimed to substantiate the patient based findings of previous studies.

PATIENTS AND METHODS: Patients with stable MS at 22 UK centres were randomised to oral cannabis extract (CE) (N=144) or placebo (N=135)... This double blind, placebo controlled, phase III study had a screening period, a 2 week dose titration phase from 5 mg to a maximum of 25 mg of tetrahydrocannabinol daily and a 10 week maintenance phase...

RESULTS: The rate of relief from muscle stiffness after 12 weeks was almost twice as high with CE than with placebo...

CONCLUSION: The study met its primary objective to demonstrate the superiority of CE over placebo in the treatment of muscle stiffness in MS. This was supported by results for secondary efficacy variables. Adverse events in participants treated with CE were consistent with the known side effects of cannabinoids. No new safety concerns were observed."
Nov. 2012 - John P. Zajicek, PhD